Research Highlights
Group Event
The He Group Publications

Roundtree, I. A.; Evans, M. E.; Pan, T.; He, C. Dynamic RNA Modifications in Gene Expression Regulation. Cell 2017, 169, 1187-1200. [pdf]



Luo, G. Z.; He, C. DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander? Nat. Struct. Mol. Biol. 2017, 24, 503-506. [pdf]



Landfors, M.; Johansen, J.; Aronsen, J. M.; Vgb, C. B.; Dor, L. C.; He, C.; Sjaastad, I.; Strom, P.; Fedorcsk P.; Dahl, J. A.; Aanes, H.; Fuer, M.; Klungland, A. Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discov. 2017, 3, 17013. [pdf]



Dai, Q.; Moshitch-Moshkovitz, S.; Han, D.; Kol, N.; Amariglio, N.; Rechavi, G.; Dominissini, D.; He, C. Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat. Methods 2017, 14, 695-698. [pdf]



Zhang, S.; Zhao, B. S.; Zhou, A.; Lin, K.; Zheng, S.; Lu, Z.; Chen, Y.; Sulman, E. P.; Xie, K.; Bgler, O.; Majumder, S.; He, C.; Huang, S. m6A demethylase ALKBH5 maintains tumorigenicity of glioblastom stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell 2017, 31, 591-606. [pdf]



Xiang, Y.; Laurent, B.; Hsu, C. H.; Nachtergaele, S.; Lu, Z.; Sheng, W.; Xu, C.; Chen, H.; Ouyang, J.; Wang, S.; Ling, D.; Hsu, P. H.; Zou, L.; Jambhekar, A.; He, C.; Shi, Y. RNA m6A methylation regulates the ultraviolet-induced DNA damage response. Nature 2017, 543, 573-576. [pdf]



Karpus, J.; Bosscher, M.; Ajiboye, I.; Zhang, L.; He, C. Chromate binding and removal by a molybdate binding protein ModA. Chembiochem. 2017, 18, 633-637. [pdf]



Cui, Q.; Shi, H,; Ye, P.; Li, L.; Qu, Q.; Sun, G.; Sun, G.; Lu, Z.; Yang, C. G.; Riggs, A. D.; He, C.*; Shi, Y.*. m6A RNA methylation regulates the self-renewal and tumorigenesis og glioblastoma stem cells. Cell Rep. 2017, 18, 2622-2634. [pdf]



Ma, L.; Zhao, B.; Chen, K.; Thomas, A.; Tuteja, J. H.; He, C.; White K. Evolution of transcript modification by N6-methyladenosine in primates. Genome Res. 2017, 27, 385-392. [pdf]



Zhao, B. S.; Wang, X.; Beadell, A. V.; Lu, Z.; Shi, H.; Kuuspalu, A.; Ho, R. K.; He, C. m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition. Nature 2017, 542, 475-478. [pdf]



Nachtergaele, S.; He, C. The emerging biology of RNA post-transcriptional modifications. RNA Biol. 2017, 14, 156-163. [pdf]



Shi, H.; Wang, X.; Lu, Z.; Zhao, B. S.; Ma, H.; Hsu, P. J.; He, C. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Cell Res. 2017, 27, 315-328. [pdf]



Li, Z.; Weng, H.; Su, R.; Weng, X.; Zuo, Z.; Li, C.; Huang, H.; Nachtergaele, S.; Dong, L.; Hu, C.; Qin, X.; Tang, L.; Wang, Y.; Hong, G. M.; Huang, H.; Wang, X.; Chen, P.; Gurbuxani, S.; Arnovitz, S.; Li, Y.; Li, S.; Strong, J.; Neilly, M. B.; Larson, R. A.; Jiang, X.; Zhang, P.; Jin, J.; He, C.*; Chen J.*. FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase. Cancer Cell. 2017, 31, 127-141. [pdf]



Zhao, B. S.; Roundtree I. A.; He,C. Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 2017, 18, 31-42. [pdf]



Weekley, C. M.; He, C. Developing drugs targeting transition metal homeostasis. Curr. Opin. Chemi. Biol. 2016, 29, 26-32. [pdf]



Shu, X.; Xiong, X.; Song, J.; He, C.*; Yi, C.*. Base-Resolution Analysis of Cisplatin-DNA Adducts at the Genome Scale. Angew. Chem. Int. Ed. 2016, 55, 14246-9. [pdf]



Sun, M.; Song, M. M.; Wei, B.; Gao, Q.; Li, L.; Yao, B.; Chen, L.; Lin, L.; Dai, Q.; Zhou, X.; Tao, J.; Chen, J.; He, C.; Jin, P.; Xu, Z. 5-hydroxymethylcytosine-mediated alteration of transposon activity associated with the exposure to adverse in utero environments in human. Hum. Mol. Genet. 2016, 25, 2208-2219. [pdf]



Lichinchi, G.; Zhao, B. S.; Wu, Y.; Lu, Z.; Qin, Y.; He, C.; Rana, T. M. Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016, 20, 666-673. [pdf]



Liu, F.; Clark, W.; Luo, G.; Wang, X.; Fu, Y.; Wei, J.; Wang, X.; Hao, Z.; Dai, Q.; Zheng, G.; Ma, H.; Han, D.; Evans, M.; Klungland, A.; Pan, T.*; He, C.*. ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell 2016, 167, 816-28. [pdf] [news]



Liu, J.; Zhu, Y.; Luo, G. Z.; Wang, X.; Yue, Y.; Wang, X.; Zong, X.; Chen, K.; Yin, H.; Fu, Y.; Han, D.; Wang, Y.*; Chen, D.*; He, C.*. Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Nat. Commun. 2016, 7, 13052. [pdf]



Han, D.; Lu, X.; Shih, A. H.; Nie, J.; You, Q.; Xu, M. M.; Melnick, A. M.; Levine, R. L.*; He, C.* . A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations. Mol. Cell 2016, 63, 711-9. [pdf]



Shi, H.; He, C. A glance at N(6)-methyladenosine in transcript isoforms. Nat. Methods 2016, 13, 624-5. [pdf]



Zahid, O. K.; Zhao, B. S; He, C.; Hall, A. R. Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores. Sci. Rep. 2016, 6, 29565. [pdf]



Tirumuru, N.; Zhao, B. S.; Lu, W.; Lu, Z.; He, C.; Wu, L. N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife 2016, 5, e15528. [pdf]



Yao, B.; Christian, K. M.; He, C.; Jin, P.; Ming, G. L.; Song, H. Epigenetic mechanisms in neurogenesis. Nucleic Acids Res. 2016, 17, 537-59. [pdf]



Yang, Y. A.; Zhao, J. C.; Fong, K. W.; Kim, J.; Li, S.; Song, C.; Song, B.; Zheng, B.; He, C.; Yu, J. FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function. Nucleic Acids Res. 2016, 44, 8153-64. [pdf]



A Alemu, E.; He, C.; Klungland, A. ALKBHs-facilitated RNA modifications and de-modifications. DNA Repair (Amst). 2016, 44, 87-91. [pdf]



von Meyenn, F.; Iurlaro, M.; Habibi, E.; Liu, N. Q.; Salehzadeh-Yazdi, A.; Santos, F.; Petrini, E.; Milagre, I.; Yu, M.; Xie, Z.; Kroeze, L. I.; Nesterova, T. B.; Jansen, J. H.; Xie, H.; He, C.; Reik, W.; Stunnenberg, H. G. Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells. Mol. Cell 2016, 62, 848-61. [pdf]



Yu, P.; Ji, L.; Lee, K. J.; Yu, M.; He, C.; Ambati, S.; McKinney, E. C.; Jackson, C.; Baile, C. A.; Schmitz, R. J.; Meagher, R. B. Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine. PLoS One 2016, 11, e0154949. [pdf]



Hohos, N. M.; Lee, K.; Ji, L.; Yu, M.; Kandasamy, M. M.; Phillips, B. G.; Baile, C. A.; He, C.; Schmitz, R. J.; Meagher, R. B. DNA cytosine hydroxymethylation levels are distinct among non-overlapping classes of peripheral blood leukocytes. J. Immunol. Methods 2016, 436, 1-15. [pdf]



Jiang, X.; Hu, C.; Arnovitz, S.; Bugno, J.; Yu, M.; Zuo, Z.; Chen, P.; Huang, H.; Ulrich, B.; Gurbuxani, S.; Weng, H.; Strong, J.; Wang, Y.; Li, Y.; Salat, J.; Li, S.; Elkahloun, A. G.; Yang, Y.; Neilly, M. B.; Larson, R. A.; Le Beau, M. M.; Herold, T.; Bohlander, S. K.; Liu, P. P.; Zhang, J.; Li, Z.; He, C.; Jin, J.; Hong, S.; Chen, J.  miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia. Nat. Commun. 2016, 7, 11452. [pdf]



Luo, G. Z.; Wang, F.; Weng, X.; Chen, K.; Hao, Z.; Yu, M.; Deng, X.; Liu, J.; He, C. Characterization of eukaryotic DNA N6-methyladenine by a highly sensitive restriction enzyme-assisted sequencing. Nat. Commun. 2016, 7, 11301. [pdf]



Bernstein, A. I.; Lin, Y.; Street, R. C.; Lin, L.; Dai, Q.; Yu, L.; Bao, H.; Gearing, M.; Lah, J. J.; Nelson, P. T.; He, C.; Levey A. I; Mullé J. G; Duan R.; Jin P. 5-hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity. Hum. Mol. Genet. 2016, 25, 2437-2450 [pdf]



Roundtree, I. A.; He, C. Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing. Trends Genet. 2016, 32, 320-321. [pdf]



Chen, K.; Zhao, B. S.; He, C. Nucleic Acid Modifications in Regulation of Gene Expression. Cell Chem. Biol. 2016, 74-85. [pdf]



Ngo, T. T.; Yoo, J.; Dai, Q.; Zhang, Q.; He, C.; Aksimentiev, A.; Ha, T. Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability. Nat. Commun. 2016, 7, 10813. [pdf]



Huang, H.; Jiang, X.; Wang, J.; Li, Y.; Song, C. X.; Chen, P.; Li, S.; Gurbuxani, S.; Arnovitz, S.; Wang, Y.; Weng, H.; Neilly, M. B.; He, C.; Li, Z.; Chen, J. Identification of MLL-fusion/MYC┫miR-26┫TET1 signaling circuit in MLL-rearranged leukemia. Cancer Lett. 2016, 372, 157-165. [pdf]



Dominissini, D.; Nachtergaele, S.; Moshitch-Moshkovitz, S.; Peer, E.; Kol, N.; Ben-Haim, M. S.; Dai, Q.; Di Segni, A.; Salmon-Divon, M.; Clark, W. C.; Zheng, G.; Pan, T.; Solomon, O.; Eyal, E.; Hershkovitz, V.; Han, D.; Doré, L. C.; Amariglio, N.; Rechavi, G.; He, C. The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA. Nature 2016, 530, 441-446. [pdf] [news]



Dominissini, D.; He, C.; Rechavi, G. RNA epigenetics. The Scientist 2016, 30, 35-39. [pdf]



Roundtree, I. A.; He, C. RNA epigenetics — chemical messages for posttranscriptional gene regulation. Curr. Opin. Chem. Bio. 2016, 30, 46-51. [pdf]



Chen, K.; Zhang, J.; Guo, Z.; Ma, Q.; Xu, Z.; Zhou, Y.; Xu, Z.; Li, Z.; Liu, Y.; Ye, X.; Li, X.; Yuan, B.; Ke, Y.; He, C.; Zhou, L.; Liu, J.; Ci, W. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Res. 2016, 26, 103-118. [pdf]



Dai, Q.; Sanstead, P. J.; Peng, C. S.; Han, D.; He, C.;* Tokmakoff, A.* Weakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing Stability. ACS Chem. Bio. 2016, 11, 470-477. [pdf]



Hu, L.; He, C. Detecting hepatocellular carcinoma in blood. Cell Res. 2015, 25, 1279-1280. [pdf]



Wang, J.; Luo, C.; Shan, C.; You, Q.; Lu, J.; Elf, S.; Zhou, Y.; Wen, Y.; Vinkenborg, J. L.; Fan, J.; Kang, H.; Lin, R.; Han, D.; Xie, Y.; Karpus, J.; Chen, S.; Ouyang, S.; Luan, C.; Zhang, N.; Ding, H.; Merkx, M.; Liu, H.; Chen, J.*; Jiang H.*; He, C.* Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat. Chem. 2015, 7, 968-979. [pdf] [news]



Hu, L.; Lu, J.; Cheng, J.; Rao, Q.; Li, Z.; Hou, H.; Lou, Z.; Zhang, L.; Li, W.; Gong, W.; Liu, M.; Sun, C.; Yin, X.; Li, J.; Tan, X.; Wang, P.; Wang, Y.; Fang, D.; Cui, Q.; Yang, P.; He, C.; Jiang, H.; Luo, C.; Xu, Y. Structural insight into substrate preference for TET-mediated oxidation. Nature 2015, 527, 118-122. [pdf]



Luo, G.-Z.; Blanco, M. A.; Greer, E. L.; He, C.*; Shi, Y.* DNA N6-methyladenine: a new epigenetic mark in eukaryotes? Nat. Rev. Mol. Cell Biol. 2015, 16, 705-710. [pdf]



Lin, R.; Elf, S.; Shan, C.; Kang, H. B.; Ji, Q.; Zhou, L.; Hitosugi, T.; Zhang, L.; Zhang, S.; Seo, J. H.; Xie, J.; Tucker, M.; Gu, T. L.; Sudderth, J.; Jiang, L.; Mitsche, M.; DeBerardinis, R. J.; Wu, S.; Li, Y.; Mao, H.; Chen, P. R.; Wang, D.; Chen, G. Z.; Hurwitz, S. J.; Lonial, S.; Arellano, M. L.; Khoury, H. J.; Khuri, F. R.; Lee, B. H.; Lei, Q.; Brat, D. J.; Ye, K.; Boggon, T. J.; He, C.; Kang, S.; Fan, J.; Chen, J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat. Cell Biol. 2015, 17, 1484-1496. [pdf]



He, C. Chemical decaging in living systems. Natl. Sci. Rev. 2015, 2, 250-251. [pdf]



Pacis, A.; Tailleux, L.; Morin, A. M.; Lambourne, J.; Maclsaac, J. L.; Yotova, V.; Dumaine, A.; Danckaert, A.; Luca, F.; Grenier, J. C.; Hansen, K. D.; Gicquel, B.; Yu, M.; Pai, A.; He, C.; Tung, J.; Pastinen, T.; Kobor, M. S.; Pique-Regi, R.; Gilad, Y.; Barreiro, L. B. Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. 2015, 25, 1801-1811. [pdf]



Xia, B.; Han, D.; Lu, X.; Sun, Z.; Zhou, A.; Yin, Q.; Zeng, H.; Liu, M.; Jiang, X.; Xie, W.; He, C.*; Yi, C.* Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale. Nat. Methods 2015, 12, 1047-1050. [pdf]



Yu, M.; Ji, L.; Neumann, D. A.; Chung, D. H.; Groom, J.; Westpheling, J.; He, C.*; Schmitz, R. J.* Base-resolution detection of N4-methylcytosine in genomic DNA using 4mC-Tet-assisted-bisulfite-sequencing. Nucleic Acids Res. 2015, 43, e148. [pdf]



Kang, H. B.; Fan, J.; Lin, R.; Elf, S.; Ji, Q.; Zhao, L.; Jin, L.; Seo, J. H.; Shan, C.; Arbiser, J. L.; Cohen, C.;, Brat, D.; Miziorko, H. M.; Kim, E.; Abdel-Wahab, O.; Merghoub, T.; Fröhling, S.; Scholl, C.; Tamayo, P.; Barbie, D. A.; Zhou, L.; Pollack, B. P.; Fisher, K.; Kudchadkar, R. R.; Lawson, D. H.; Sica, G.; Rossi, M.; Lonial, S.; Khoury, H. J.; Khuri, F. R.; Lee, B. H.; Boggon, T. J.; He, C.; Kang, S.; Chen, J. Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Mol. Cell 2015, 59, 345-358. [pdf]



Wang, L.; Zhou, Y.; Xu, L.; Xiao, R.; Lu, X.; Chen, L.; Chong, J.; Li, H.; He, C.; Fu, X. D.; Wang, D. Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature 2015, 523, 621-625. [pdf]



Zheng, G.; Qin, Y.; Clark, W. C.; Dai, Q.; Yi, C.; He, C.; Lambowitz, A. M.; Pan, T. Efficient and quantitative high-throughput tRNA sequencing. Nat. Methods 2015, 12, 835-837. [pdf]



Yue, Y.; Liu, J.; He, C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev. 2015, 29, 1343-1355. [pdf]



Deng, X.; Chen, K.; Luo, G. Z.; Weng, X.; Ji, Q.; Zhou, T.; He, C. Widespread occurrence of N6-methyladenosine in bacterial mRNA. Nucleic Acids Res. 2015, 43, 6557-6567. [pdf]



He, C. Decoding the transcriptome and DNA methylome of human primordial germ cells. Sci. China Life Sci. 2015, 58, 729-730. [pdf]



Wang, X.; Zhao, B. S.; Roundtree, I. A.; Lu, Z.; Han, D.; Ma, H.; Weng, X.; Chen, K.; Shi, H.; He, C. N6-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell 2015, 161, 1388-1399. [pdf]



Greer, E. L.; Blanco, M. A.; Gu, L.; Sendinc, E.; Liu, J.; Aristizábal-Corrales, D.; Hsu, C. H.; Aravind, L.; He, C.; Shi, Y. DNA Methylation on N6-Adenine in C. elegans. Cell 2015, 161, 868-878. [pdf]



Fu, Y.; Luo, G. Z.; Chen, K.; Deng, X.; Yu, M.; Han, D.; Hao, Z.; Liu, J.; Lu, X.; Doré, L. C.; Weng, X.; Ji, Q.; Mets, L.; He, C. N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas. Cell 2015, 161, 879-892. [pdf]



Zhang, G.; Huang, H.; Liu, D.; Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J.; Li, C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.; Chen, D. N6-methyladenine DNA modification in Drosophila. Cell 2015, 161, 893-906. [pdf]



Cheglakov, Z.; Cronin, T. M.; He, C.; Weizmann, Y. Live Cell MicroRNA Imaging Using Cascade Hybridization Reaction. J. Am. Chem. Soc. 2015, 137, 6116-6119. [pdf]



Song, Y.; Yang, M.; Wegner, S. V.; Zhao, J.; Zhu, R.; Wu, Y.; He, C.; Chen, P. R. A Genetically Encoded FRET Sensor for Intracellular Heme. ACS Chem. Biol. 2015. 17, 1610-1615. [pdf]



He, C.; Cole, P. Introduction: epigenetics. Chem. Rev. 2015, 115, 2223-2224. [pdf]



Zhao, B. S.; He, C. Fate by RNA methylation: m6A steers stem cell pluripotency. Genome Biol. 2015, 16, 43. [pdf]



Liu, N.; Dai, Q.; Zheng, G.; He, C.; Parisien, M.; Pan, T. N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature 2015, 518, 560-564. [pdf]



Lu, X.; Zhao, B. S.; He, C. TET family proteins: oxidation activity, interacting molecules, and functions in diseases. Chem. Rev. 2015, 115, 2225-2239. [pdf]



Jin, L.; Li, D.; Alesi, G. N.; Fan, J.; Kang, H. B.; Lu, Z.; Boggon, T. J.; Jin, P.; Yi, H.; Wright, E. R.; Duong, D.; Seyfried, N. T.; Egnatchik, R.; DeBerardinis, R. J.; Magliocca, K. R.; He, C.; Arellano, M. L.; Khoury, H. J.; Shin, D. M.; Khuri, F. R.; Kang, S. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell 2015, 27, 257-270. [pdf]



Lu, X.; Han, D.; Zhao, B. S.; Song, C. X.; Zhang, L. S.; Dore, L. C.; He, C. Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics. Cell Res. 2015, 25, 386-389. [pdf]



Chen, X.; Velmurugu, Y.; Zheng, G.; Park, B.; Shim, Y.; Kim, Y.; Liu, L.; Van Houten, B.; He, C.; Ansari, A.; Min, J. H. Kinetic gating mechanism of DNA damage recognition by Rad4/XPC. Nat. Commun. 2015, 6, 5849. [pdf]



Chen, K.; Lu, Z.; Wang, X.; Fu, Y.; Luo, G. Z.; Liu, N.; Han, D.; Dominissini, D.; Dai, Q.; Pan, T.; He, C. High-Resolution N(6) -Methyladenosine (m(6) A) Map Using Photo-Crosslinking-Assisted m(6) A Sequencing. Angew. Chem. Int. Ed. 2015, 54, 1587-1590. [pdf]



Yu, M.; Song, C. X.; He, C. Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling. Methods 2015, 72, 16-20. [pdf]



Zhao, B. S.; He, C. Pseudouridine in a new era of RNA modifications. Cell Res. 2015, 25, 153-154. [pdf]



He, C. Visualizing a protein's sugars. Natl. Sci. Rev. 2014, 1, 480-481. [pdf]



Tsai, Y. P.; Chen, H. F.; Chen, S. Y.; Cheng, W. C.; Wang, H. W.; Shen, Z. J.; Song, C.; Teng, S. C.; He, C.; Wu, K. J. TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator. Genome Biol. 2014, 15, 513. [pdf]



Rampal, R.; Alkalin, A.; Madzo, J.; Vasanthakumar, A.; Pronier, E.; Patel, J.; Li, Y.; Ahn, J.; Abdel-Wahab, O.; Shih, A.; Lu, C.; Ward, P. S.; Tsai, J. J.; Hricik, T.; Tosello, V.; Tallman, J. E.; Zhao, X.; Daniels, D.; Dai, Q.; Ciminio, L.; Aifantis, I.; He, C.; Fuks, F.; Tallman, M. S.; Ferrando, A.; Nimer, S.; Paietta, E.; Thompson, C. B.; Licht, J. D.; Mason, C. E.; Godley, L. A.; Melnick, A.; Figueroa, M. E.; Levine, R. L. DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia. Cell Rep. 2014, 9, 1841-1855. [pdf]



Luo, G. Z.; MacQueen, A.; Zheng, G.; Duan, H.; Dore, L. C.; Lu, Z.; Liu, J.; Chen, K.; Jia, G.; Bergelson, J.; He, C. Unique features of the m(6)A methylome in Arabidopsis thaliana. Nat. Commun. 2014, 5, 5630. [pdf]



Zhao, X.; Yang, Y.; Sun, B. F.; Shi, Y.; Yang, X.; Xiao, W.; Hao, Y. J.; Ping, X. L.; Chen, Y. S.; Wang, W. J.; Jin, K. X.; Wang, X.; Huang, C. M.; Fu, Y.; Ge, X. M.; Song, S. H.; Jeong, H. S.; Yanagisawa, H.; Niu, Y.; Jia, G. F.; Wu, W.; Tong, W. M.; Okamoto, A.; He, C.; Rendtlew Danielsen, J. M.; Wang, X. J.; Yang, Y. G. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 2014, 24, 1403-1419. [pdf]



Zhu, T.; Roundtree, I. A.; Wang, P.; Wang, X.; Wang, L.; Sun, C.; Tian, Y.; Li, J.; He, C.; Xu, Y. Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell Res. 2014, 24, 1493-1496. [pdf]



Odoh, S. O.; Bondarevsky, G. D.; Karpus, J.; Cui, Q.; He, C.; Spezia, R.; Gagliardi, L. UO Uptake by Proteins: Understanding the Binding Features of the Super Uranyl Binding Protein and Design of a Protein with Higher Affinity. J. Am. Chem. Soc. 2014, 136, 17484-17494. [pdf]



Wang, X.; He, C. Dynamic RNA modifications in posttranscriptional regulation. Mol. Cell. 2014, 56, 5-12. [pdf]



Deng, X.; Liang, H.; Chen, K.; He, C.; Lan, L.; Tang, X. Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae. Nucleic Acids Res. 2014, 42, 11472-11486. [pdf]



Hon, G. C.; Song, C. X.; Du, T.; Jin, F.; Selvaraj, S.; Lee, A. Y.; Yen, C. A.; Ye, Z.; Mao, S. Q.; Wang, B. A.; Kuan, S.; Edsall, L. E.; Zhao, B. S.; Xu, G. L.; He, C.; Ren, B. 5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation. Mol. Cell. 2014, 56, 286-297. [pdf]



Xu, C.; Wang, X.; Liu, K.; Roundtree, I. A.; Tempel, W.; Li, Y.; Lu, Z.; He, C.; Min, J. Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain. Nat. Chem. Biol. 2014, 10, 927-929. [pdf]



Nazor, K. L.; Boland, M. J.; Bibikova, M.; Klotzle, B.; Yu, M.; Glenn-Pratola, V. L.; Schell, J. P.; Coleman, R. L.; Cabral-da-Silva, M. C.; Schmidt, U.; Peterson, S. E.; He, C.; Loring, J. F.; Fan, J. B. Application of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells. Genomics 2014, 104, 358-367. [pdf]



Cheng, Y.; Dai, Q.; Morshed, R. A.; Fan, X.; Wegscheid, M. L.; Wainwright, D. A.; Han, Y.; Zhang, L.; Auffinger, B.; Tobias, A. L.; Rincon, E.; Thaci, B.; Ahmed, A. U.; Warnke, P. C.; He, C.; Lesniak, M. S. Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging. Small 2014, 10, 5137-5150. [pdf]



Shan, C.; Elf, S.; Ji, Q.; Kang, H. B.; Zhou, L.; Hitosugi, T.; Jin, L.; Lin, R.; Zhang, L.; Seo, J. H.; Xie, J.; Tucker, M.; Gu, T. L.; Sudderth, J.; Jiang, L.; DeBerardinis, R. J.; Wu, S.; Li, Y.; Mao, H.; Chen, P. R.; Wang, D.; Chen, G. Z.; Lonial, S.; Arellano, M. L.; Khoury, H. J.; Khuri, F. R.; Lee, B. H.; Brat, D. J.; Ye, K.; Boggon, T. J.; He, C.; Kang, S.; Fan, J.; Chen, J. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol. Cell. 2014, 55, 552-565. [pdf]



Zheng, G.; Cox, T.; Tribbey, L.; Wang, G. Z.; Iacoban, P.; Booher, M. E.; Gabriel, G. J.; Zhou, L.; Bae, N.; Rowles, J.; He, C.; Olsen, M. J. Synthesis of a FTO inhibitor with anticonvulsant activity. ACS Chem. Neurosci. 2014, 5, 658-665. [pdf]



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He, Y. F.; Li, B. Z.; Li, Z.; Liu, P.; Wang, Y.; Tang, Q.; Ding, J.; Jia, Y.; Chen, Z.; Li, L.; Sun, Y.; Li, X.; Dai, Q.; Song, C. X.; Zhang, K.; He, C.; Xu, G. L. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011, 333, 1303-1307.[pdf]



Brugarolas, P.; Duguid, E. M.; Zhang, W.; Poor, C. B.; He, C. Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus. Acta Crystallogr. D Biol. Crystallogr. 2011, 67, 707-715.[pdf]



Ito, S.; Shen, L.; Dai, Q.; Wu, S. C.; Collins, L. B.; Swenberg, J. A.; He, C.; Zhang, Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011, 333, 1300-1303. [pdf]



Szulwach, K. E.; Li, X.; Li, Y.; Song, C. X.; Han, J. W.; Kim, S.; Namburi, S.; Hermetz, K.; Kim, J. J.; Rudd, M. K.; Yoon, Y. S.; Ren, B.; He, C.; Jin, P. Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet. 2011, 7, e1002154.[pdf]



Moran-Crusio, K.; Reavie, L.; Shih, A.; Abdel-Wahab, O.; Ndiaye-Lobry, D.; Lobry, C.; Figueroa, M. E.; Vasanthakumar, A.; Patel, J.; Zhao, X.; Perna, F.; Pandey, S.; Madzo, J.; Song, C.; Dai, Q.; He, C.; Ibrahim, S.; Beran, M.; Zavadil, J.; Nimer, S. D.; Melnick, A.; Godley, L. A.; Aifantis, I.; Levine, R. L. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 2011, 20, 11-24.[pdf]



Song, C. X.; Sun, Y.; Dai, Q.; Lu, X. Y.; Yu, M.; Yang, C. G.; He, C. Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage beta-glucosyltransferase. ChemBioChem 2011, 12, 1682-1685.[pdf]



Dai, Q.; He, C. Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA. Org. Lett. 2011, 13, 3446-3449.[pdf]



Dolan, K. T.; Duguid, E. M.; He, C. Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states. J. Biol. Chem. 2011, 286, 22178-22185.[pdf]



Song, C. X.; He, C. Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes. Acc. Chem. Res. 2011, 44, 709-717.[pdf]



Song, C. X.; Yu, M.; Dai, Q.; He, C. Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(alpha)I. Bioorg. Med. Chem. Lett. 2011, 21, 5075-5077.[pdf]



Dai, Q.; Song, C. X.; Pan, T.; He, C. Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA. J. Org. Chem. 2011, 76, 4182-4188.[pdf]



Wegner, S.V.; Sun, F.; Hernandez, N.; He, C.; "The tightly regulated copper window in yeast." Chem. Commun. 2011, 47, 2571-2573. [pdf]


Song, C. X.; Szulwach, K. E.; Fu, Y.; Dia, Q.; Yi, C.; Li, X.; Li, Y.; Chen, C.-H.; Zhang, W.; Jian, X.; Wang, J.; Zhang, L.; Looney, T. J.; Zhang, B.; Godley, L. A.; Hicks, L. M.; Lahn, B. T.; Jin, P.*; He, C.* Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol. 201129, 68-72. [pdf]


Wegner, S. V.; Ertem, E.; Sunbul, M.; He, C. Metal-binding properties of Hpn from Helicobacter pylori and implications for the therapeutic activity of bismuth. Chem. Sci. 2011, 2, 451-456.[pdf]


Chen, P. R.; Brugarolas, P.; He, C. Redox Signaling in Human Pathogens. Antioxid. Redox Signal. 2011, 107-1118. [pdf]


Sun, F.; Cho, H.; Jeong, D. W.; Li, C.; He, C.; Bae, T. Aureusimines in Staphylococcus aureus are not involved in virulence. PLoS One 2010, 5, e15703 [pdf]


Yi, C.; Jia, G; Hou, G.; Dai, Q.; Zhang, W.; Zheng, G.; Jian, X.; Yang, C.-G.; Cui, Q.; He, C. Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature 2010, 468, 330-333.[pdf]

80. He, C. Grand Challenge Commentary: RNA epigenetics? Nat. Chem. Bio. 2010, 6, 863-865.[pdf]


Chen, H.; Yi, C.; Zhang, J.; Zhang, W.; Ge, Z.; Yang, C.-G.; He, C. Structural insight into the oxidation sensing mechanism of the antibiotic resistance regulator MexR. EMBO Rep. 2010, 11, 685-690. [pdf]


Li, C.; Sun, F.; Cho, H.; Yelavarthi, V.; Sohn, C.; He, C.; Schneewind, O.; Bae, T. CcpA mediates proline auxotrophy and is required for the pathogenesis of Staphylococcus aureus infections. J. Bacteriol. 2010, 3883-3892. [pdf]


Li, Y.; He. C.*; Jin, P.* Emergence of Chemical Biology Approaches to the RNAi/miRNA Pathway. Chem. Biol. 2010, 17, 584-589. [pdf]


Fu, Y.; Dai, Q.; Zhang, W.; Ren, J.; Pan, T.; He, C. The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5-Methoxycarbonylmethyluridine at the Wobble Position of tRNA Angew. Chem. Intl. Ed. 2010, 49, 8885-8888. [pdf]


Saikia, M.; Fu, Y.; Pavon-Eternod, M.; He, C.; Pan, T. Genome-wide Analysis of N1-methyl-adenosine Modification in Human tRNAs. RNA 2010, 1317-1327. [pdf]

74. Lan, L.; Cheng, A.; Dunman, P. M.; Missiakas, D; He, C. Golden Pigment Production and Virulence Gene Expression are Affected by Metabolisms in Staphylococcus aureus. J. Bacteriol. 2010, 192, 3068-3077. [pdf]


Lu, L.; Yi, C.; Jian, X.; Zheng, G.; He, C. Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system. Nucleic Acids Res. 2010, 4415-4425. [pdf]


Sun, F.; Li, C.; Jeong, D.; Sohn, C.; He, C.; Bae, T. In the Staphylococcus aureus two component system sae, the response regulator SaeR binds to a direct repeat sequence and the DNA binding requires phosphorylation by the sensor kinase SaeS. J. Bacteriol. 2010, 192, 2111-2127. [pdf]


Wegner, S.; Arslan, H.; Sunbul, M.; Yin, J; He, C. Dynamic Copper(I) Imaging in Mammalian Cells with a Genetically Encoded Fluorescent Copper(I) Sensor. J. Am. Chem. Soc. 2010, , 132 , 2567-2569. [pdf]


Lan, L.; Murray, T. S.; Kazmierczak, B. I.; He, C. Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection. Mol. Microbiol. 2010, 75, 76-91. [pdf]


Yi, C. and He, C. AlkB recognition of a bulky DNA base adduct stabilized by chemical cross-linking. Sci. China. Chem. 2010, 53, 86.


Budzik, J. M.; Poor, C. B.; Faull, K. F.; Whitelegge, J. P.; He, C.*; Schneewind, O.* Intermolecular amide bonds stabilize pili on the surface of bacilli. Proc. Natl. Acad. Sci 2009, 106, 19992-19997. [pdf]

67. Jian, X.; Wasinger, E. C.; Lockard, J. V.; Chen, L. X.; He, C. Highly Sensitive and Selective Gold(I) Recognition by a Metalloregulator in Ralstonia metallidurans. J. Am. Chem. Soc. 2009, 131, 10869-10871. [pdf]


Poor, C. B.; Chen, P. R.; Duguid, E.; Rice, P. A.; He, C. Crystal structures of the reduced, sulfenic acid and mixed disulfide forms of sarz, a redox active global regulator in staphylococcus aureus. J. Biol. Chem. 2009, 284, 23517-23524. [pdf]


Lin, Y.; Zhao, T.; Jian, X.; Farooqui, Z.; Qu, X.; He, C.; Dinner, A. R.; Scherer, N. F. Using the Bias from Flow to Elucidate Single DNA Repair Protein Sliding and Interactions with DNA. 2009, 96, 1911-1917. [pdf]

Yang, S.; Li, Z.; Jian, X; He, C. Platinum(II)-Catalyzed Intramolecular Cyclization of o-Substituted Arylalkynes through sp3 C-H Activation. 2009, 48, 3999-4001. [pdf]


Wegner, S. V.; Boyaci, H.; Chen, H.; Jensen, M. P.; He, C. Engineering a Uranyl-Specific Binding Protein from NikR. Angew. Chem. Intl. Ed. 2009, 48, 2339-2341. [pdf] [press]

62. Yi, C.; Yang, C.-G.; He, C. A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA. Acc. Chem. Res. 2009, 42, 519-529. [pdf]
61. Yang, C.-G.; Garcia, K.; He, C. Damage Detection and Base Flipping in Direct DNA Alkylation Repair. ChemBioChem 2009, 10, 417-423. [pdf]
60. Richter, S; Anderson, V. J.; Garufi, G.; Lu, L.; Budzik, J. M.; Joachimiak, A.; He, C.; Schneewind, O.; Missiakas, D. Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin. Mol. Microbiol. 2009, 71, 404-420. [pdf]
59. Chen, P. R.; Nishida, S.; Poor, C. B.; Cheng, A.; Bae, T.; Kuechenmeister, L.; Dunman, P. M.; Missiakas, D.; He, C. A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus. Mol. Microbiol. 2009, 71, 198-211. [pdf]
58. Shigdel, U. K. and He, C. A New 1'-Methylenedisulfide Deoxyribose that Forms an Efficient Cross-Link to DNA Cytosine-5 Methyltransferase (DNMT). J. Am. Chem. Soc. 2008, 130, 17634-17635. [pdf]
57. Qiu, Z.; Lu, L.; Jian, X.; He, C. A Diazirine-Based Nucleoside Analogue for Efficient DNA Interstrand Photocross-Linking. J. Am. Chem. Soc. 2008, 130, 14398-14399. [pdf]
56. Jia, G.; Yang, C.-G.; Yang, S.; Jian, X.; Yi, C.; Zhou, Z.; He, C. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Letters 2008, 582, 3313-3319. [pdf]
55. Chen, H.; Hu, J.; Chen, P. R.; Lan, L.; Li, Z.; Hicks, L. M.; Dinner, A. R; He, C. The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism. Proc. Natl. Acad. Sci. 2008, 105, 13586-13591. [pdf]
54. Li, X.; Ye, S.; He, C.; Yu, Z.-X. Mechanisms of Brønsted Acid Catalyzed Additions of Phenols and Protected Amines to Olefins: A DFT Study. Eur. J. Org. Chem. 2008, 25, 4296-4303. [pdf]
53. Shan, G.; Li, Y.; Zhang, J.; Li, W.; Szulwach, K. E.; Duan, R.; Faghihi, M. A.; Khalil, A. M.; Lu, L.; Paroo, Z.; Chan, A. W. S.; Shi, Z.; Liu, Q.; Wahlestedt, C.; He, C.; Jin, P. A small molecule enhances RNA interference and promotes microRNA processing. Nature Biotechnology 2008, 26, 933-940. [pdf] [C&EN]
52. Li, Z.; Brouwer, C.; He, C. Gold-Catalyzed Organic Transformations Chem. Rev. 2008, 108, 3239-3265. [pdf]
51. Yang, C.-G.; Yi, C.; Duguid, E. M.; Sullivan, C. T.; Jian, X.; Rice, P. A.; He, C. Crystal structures of DNA-RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature 2008, 452, 961-965. [pdf] [U. Chicago Press] [C&EN] [AAAS] [Argonne Lab Press] (For additional news links, go to "Research Highlights"
50.  Chen, P. R. and He, C.  Selective recognition of metal ions by metalloregulatory proteins. Curr. Opin. Chem. Biol. 2008, 12, 214-221. [pdf]
49.  Chang, S.; Bray, S. M.; Li, Z.; Zarnescu, D. C.; He, C.; Jin, P.; Warren, S. T.  Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat. Chem. Biol. 2008,  4, 256-263. [pdf]
48.  Shigdel, U. K.; Zhang, J.; He, C. Diazirine-Based DNA Photo-Cross-Linking Probes for the Study of Protein-DNA Interactions. Angew. Chem. Intl. Ed. 2008, 47, 90-93. [pdf]
47.  Chen, C.-S.; Korobkova, E.; Chen, H.; Zhu, J.; Jian, X.; Tao, S.-C.; He, C.*; Zhu, H.* A proteome chip approach reveals new DNA damage recognition activities in Escherichia Coli Nat. Methods, 2008, 5, 69-74. [pdf] [J. Proteome Res. press]
46.  Durek, T.; Zhang, J.; He, C.; Kent, S. B.H . Synthesis of Photoactive Analogues of a Cysteine Knot Trypsin Inhibitor Protein Org. Lett. 2007, 9, 5497-5500.   [pdf]
45. Sarkar, S. K.; Andoy, N. M.; Benitez, J. J.; Chen, P. R.; Kong, J. S.; He, C.; Chen, P. Engineered Holliday Junctions as Single-Molecule Reporters for Protein-DNA Interactions with Application to a MerR-Family Regulator. J. Am. Chem. Soc. 2007, 129, 12461-12467.  [pdf]

44. Chen, P. R.; Wasinger, E. C.; Zhao, J.; van der Lelie, D.; Chen, L. X. ; He, C. Spectroscopic Insights into Lead(II) Coordination by the Selective Lead(II)-Binding Protein PbrR691. J. Am. Chem. Soc. 2007, 129, 12350-12351. [pdf]

43. Li, Z.; Capretto, D. A.; Rahaman, R. O.; He, C. Gold(III)-Catalyzed Nitrene Insertion into Aromatic and Benzylic C-H Groups. J. Am. Chem. Soc.  2007, 129, 12058-12059. [pdf]

42. Brouwer, C.; Rahatrian, R.; He, C. Gold(I)-Mediated Hydrothiolation of Conjugated Olefins. Synlett 2007, 11, 1785-1789. [pdf]

41. Li, Z.; Capretto, D. A.; Rahaman, R. O.; He, C. Silver-Catalyzed Intermolecular Amination of C-H Groups. Angew. Chem. Intl. Ed. 2007, 46, 5184-5186. [pdf] [C&EN]

40. Wegner, S. V.; Okesli, A.; Chen, P.; He, C. Design of an Emission Ratiometric Biosensor from MerR Family Proteins: A Sensitive and Selective Sensor for Hg2+. J. Am. Chem. Soc. 2007, 129, 3474-3475. [pdf]

39. Chen, P.; Bae, T.; Williams, W. A.; Duguid, E. M.; Rice, P. A.; Schneewind, O. and He, C. An Oxidation Sensing Mechanism is Used by A Global Regulator of Staphylococcus aureus. Nature Chem. Biol. 2006, 2, 591-595. [pdf] [C&EN] [IDBD Listing]


Li, Z.; Zhang, J.; Brouwer, C.; Yang, C.-G.; Reich, N. W. and He, C. Bronsted Acid Catalyzed Addition of Phenols, Carboxylic Acids and Tosylamides to Simple Olefin. Org. Lett. 2006, 8:4175-8.  [pdf]


37. Li, Z.; Ding, X. and He, C. Nitrene Transfer Reactions Catalyzed by Gold Complexes. J. Org. Chem. 2006, 71:5876-80.  [pdf]
36. Li, Z. and He, C. Recent Advances in Silver-Catalyzed Nitrene, Carbene, and Silylene-Transfer Reactions. Euro. J. Org. Chem. 2006, 4313-4322.[pdf]
Mishina, Y. and He, C. Oxidative Dealkylation DNA Repair Mediated by the Mononuclear Non-Heme
 Iron AlkB Proteins. J. Inorg. Biochem. 2006, 100, 670-678. [pdf] 
Reich, N. W.; Yang, C.-G.; Shi, Z. and He, C. Gold(I)-Catalyzed Synthesis of Dihydrobenzofurans from
 Aryl Allyl Ethers. Synlett. 2006, 8, 1278-1280. [pdf] 


Brouwer, C. and He, C. Efficient Gold-Catalyzed Hydroamination of 1,3-Dienes. Angew Chem. Int. Ed. 2006, 45, 1744-1747. [pdf]



Zhang, J.; Yang, C.-G. and He, C. Gold(I)-Catalyzed Intra- and Intermolecular Hydroamination of Unactivated Olefins. J. Am. Chem. Soc. 2006, 128, 1798-1799. [pdf]



Mishina, Y.; Duguid, M. E. and He, C. Direct Reversal of DNA Alkylation Damage. Chem. Rev. 2006, 106, 215-232.  [pdf]




Yang, C.-G.; Reich, N. W. and He, C. Intramolecular Additions of Alcohols and Carboxylic Acids to Inert Olefins Catalyzed by Silver(I) Triflate. Org. Lett. 2005, 7, 4553-4556. [pdf]



Mishina, Y.; Yang, C.-G. and He, C. Direct Repair of the Exocyclic DNA Adduct 1,N6-Ethenoadenine by E. coli AlkB and Human ABH3. J. Am. Chem. Soc. 2005, 127, 14594-14595. [pdf]



Li, Z.; Shi, Z. and He, C. Addition of Heterocycles to Electron Deficient Olefins and Alkynes Catalyzed by Gold(III). J. Organom. Chem. 2005, 690, 5049-5054. [pdf]



Yang, C.-G. and He, C. Gold(I)-Catalyzed Intermolecular Addition of Phenols and Carboxylic Acids to Olefins. J. Am. Chem. Soc. 2005, 127, 6966-6967. [pdf]



Duguid, M. E.; Rice, P. A. and He, C. Implications for How the Human DNA Repair Protein AGT Locates Damage as Revealed from A Unique X-ray Structure of Its DNA Bound Form. J. Mol. Biol. 2005, 350, 657-666. [pdf]



Chen, P.; Greenberg, B.; Taghavi, S.; Romano, C.; van der Lelie, D. and He, C. An Exceptionally Selective Lead(II)-Regulatory Protein from Ralstonia Metallidurans: Development of A Fluorescent Lead(II) Probe. Angew Chem. Int. Ed. 2005, 44, 2715-2719.  [pdf]   C&EN, News1 News2 News3 News4  News5 News6



He, C.; Sun, L. J.; Zhou, P.; Norman, D. P. G.; Dötsch, V.; Gross, J. D.; Lane, W. S.; Wagner, G.; Verdine, G. L. A Zinc-Mediated Electrostatic Switch Controls the Adaptive Response of E. coli to Methylating Agents. Mol. Cell. 2005, 20, 117-129. [pdf]



Mishina, Y.; Chen, L. X. and He, C. Preparation and Characterization of the Native Iron(II)-Containing AlkB Protein Directly from Escherichia coli. J. Am. Chem. Soc. 2004,  126, 16930-16936. [pdf]



Shi, Z. and He, C. Direct Functionalization of Arenes by Primary Alcohol Sulfonate Esters Catalyzed by Gold(III). J. Am. Chem. Soc. 2004, 126, 13596-13597. [pdf]



Cui, Y. and He, C. A Silver-Catalyzed Intramolecular Amidation of Saturated CH bonds. Angew Chem. Int. Ed. 2004, 43, 4210-4212. [pdf]



Shi, Z. and He, C. Efficient Functionalization of Aromatic CH Bonds Catalyzed by Gold(III) under Mild and Solvent Free Conditions. J. Org. Chem. 2004, 69, 3669-3671. [pdf]



Shi, Z. and He, C. An Au-Catalyzed Cyclialkylation of Electron Rich Arenes with Epoxides to Prepare 3-Chromanols. J. Am. Chem. Soc. 2004, 126, 5964-5965. [pdf]



Mishina, Y.; Lee, C.-H. J. and He, C. Potential DNA Preferences of Human and Bacterial AlkB Proteins as Revealed from Chemical Crosslink Studies. Nucleic Acids Res. 2004, 32, 1548-1554.  [pdf]



He, C. and Mishina, Y. Modeling non-heme iron proteins. Curr. Opin. Chem. Biol. 2004, 8, 201-208. [pdf]



Chen, P. and He, C. A General Strategy to Convert the MeR Family Proteins Into Highly Sensitive and Selective Fluorescent Biosensors for Metal Ions. J. Am. Chem. Soc. 2004, 126, 728-729. [pdf], C&EN  Analytical Chemistry




Cui, Y. and He, C. Efficient Aziridination of Olefins Catalyzed by A Unique Disilver(I) Compound. J. Am. Chem. Soc. 2003, 125, 16202-16203. [pdf]



Duguid, E. M.; Mishina, Y. and He, C. A Chemical Disulfide Crosslinking Method to Investigate the Damage-Searching Mechanism of O6-Alkylguanine-DNA Alkyltransferases. Chem. & Biol. 2003, 10, 827-835. [pdf]



Mishina, Y. and He, C. Probing the Structure and Function of E. coli DNA Alkylation Repair AlkB Protein through Chemical Crosslinking. J. Am. Chem. Soc.  2003, 125, 8730-8731. [pdf]


Other Publications

12.  He, C.; Wei, H.; Verdine, G. L. Converting the Sacrificial DNA Repair Protein N-Ada into a Catalytic Methyl Phosphotriester Repair Enzyme. J. Am. Chem. Soc. 2003, 125, 1450-1451.

11.  He, C.; Verdine, G. L. Trapping Distinct Structural States of a Protein/DNA Interaction through Disulfide Cross-linking. Chem. & Biol. 2002, 9, 1297-1303.

10.  He, C.; DuBois, J. L.; Hedman, B.; Hodgson, K. O.; Lippard, S. J. A short Copper-Copper Distance in a (m-1,2-Peroxo)dicopper(II) Complex Having 1,8-Naphthyridine Unit as an Additional Bridge. Angew. Chem. Int. Ed. 2001, 40, 1484-1487.

9.  He, C.; Lippard, S. J. Synthesis and Electrochemical Studies of Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands to Model Features of the Active Sites of Non-Heme Diiron Enzymes. Inorg. Chem. 2001, 40, 1414-1420 (cover story).

8.  He, C.; Barrios, A. M.; Lee, D.; Kuzelka, J.; Davydov, R. M.; Lippard, S. J. Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands as Models for Hemerythrin. J. Am. Chem. Soc. 2000, 122, 12683-12690.

7.   He, C.; Lippard, S. J. Synthesis and Characterization of Several Dicopper(I) Complexes and a Spin-Delocalized Dicopper(I,II) Mixed-Valence Complex Using a 1,8-Naphthyridine-Based Dinucleating Ligand. Inorg. Chem. 2000, 39, 5225-5231.

6.  He, C.; Lippard, S. J. Design and Synthesis of Multidentate Dinucleating Ligands Based on 1,8-Naphthyridine. Tetrahedron 2000, 56, 8245-8252.

5.  He, C.; Gomez, V.; Spingler, B.; Lippard, S. J. Monodentate-Bridged Phosphodiester and Sulfate Complexes: Structural Insight into the Biological Activation of Phosphodiesters, Sulfate, and Sulfate Esters. Inorg. Chem. 2000, 39, 4188-4189.

4.  Kaminskaia, N. V.; He, C.; Lippard, S. J. Reactivity of m-Hydroxodizinc(II) Centers in Enzymatic Catalysis through Model Studies. Inorg. Chem. 2000, 39, 3365-3373.

3.  He, C.; Lippard, S. J. Modeling Carboxylate-Bridged Dinuclear Active Sites in Metalloenzymes Using a Novel Naphthyridine-Based Dinucleating Ligand. J. Am. Chem. Soc. 2000, 122, 184-185.

2.  He, C.; Lippard, S. J. Aminoguanidinium Hydrolysis Effected by a Hydroxo-Bridged Dicobalt(II) Complexes. J. Am. Chem. Soc. 1998, 120, 105-113.

1.  Qian, Y.; Xie, Y.; He, C.; Li, J.; Chen, Z. Hydrothermal Preparation and Characterization of Ultrafine Magnetite Powders. Material Research Bulletin 1994, 29, 953-957.