Recent Publications:

Yi, C.; Jia, G; Hou, G.; Dai, Q.; Zhang, W.; Zheng, G.; Jian, X.; Yang, C.-G.; Cui, Q.; He, C.; "Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase" Nature 2010, 468, 330.[pdf] [news]

Zhang, L.; Lu, X.Y.; Lu, J.Y.; Liang, H.H.; Dai, Q.; Xu, G.L.; Luo, C.; Jiang, H.L.; He, C. Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat. Chem. Biol. 2012. ahead of print. [pdf]

Song, C. X.; Clark, T. A.; Lu, X. Y.; Kislyuk, A.; Dai, Q.; Turner, S. W.; He, C.; Korlach, J. Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine. Nat. Methods. 2012. ahead of print.[pdf]

Jia, G.; Fu, Y.; Zhao, X.; Dai, Q.; Zheng, G.; Yang, Y.; Yi, C.; Lindahl, T.; Pan, T.; Yang, Y. G.; He, C. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 2011, 7, 885-887.[pdf] [news]

Qian, Y.; Karpus, J.; Kabil, O.; Zhang, S. Y.; Zhu, H. L.; Banerjee, R.; Zhao, J.; He, C. Selective fluorescent probes for live-cell monitoring of sulphide. Nat. Commun. 2011, 2, 495.[pdf][news]

He, Y. F.; Li, B. Z.; Li, Z.; Liu, P.; Wang, Y.; Tang, Q.; Ding, J.; Jia, Y.; Chen, Z.; Li, L.; Sun, Y.; Li, X.; Dai, Q.; Song, C. X.; Zhang, K.; He, C.; Xu, G. L. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011, 333, 1303-1307.[pdf]

Ito, S.; Shen, L.; Dai, Q.; Wu, S. C.; Collins, L. B.; Swenberg, J. A.; He, C.; Zhang, Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011, 333, 1300-1303. [pdf]

Song, C.X.; Szulwach, K.E.; Fu, Y.; Dia, Q.; Yi, C.; Li, X.; Li, Y.; Chen, C.-H.; Zhang, W.; Jian, X.; Wang, J.; Zhang, L.; Looney, T.J.; Zhang, B.; Godley, L.A.; Hicks, L.M.; Lahn, B.T.; Jin, P.; He, C. "Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine" Nat. Biotechnol.2011, 29, 68.[pdf][news]

News!

08/25/2011: Opening Ceremony- Synthetic and Functional Biomolecules Center (SFBC)-PKU. [news]