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Welcome to the He Group!



He Lab breakthrough has major implications in basic biology UChicago News


Prof. Chuan He to lead Chicago's first Center of Excellence in Genomic Science (CEGS) More...


Recent Publications:

Zhang, Z.; Luo, K.; Zou, Z.; Qiu, M.; Tian, J.; Sieh, L.; Shi, H.; Zou, Y.; Wang, G.; Morrison, J.; Zhu, A. C.; Qian, M.; Li, Z.; Stephens, M.*; He, X.*; He, C.* Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability. Nat. Genet. 2020, on-line. [pdf]

You, Q.; Cheng, A. Y.; Gu, X.; Harada, B. T.; Yu, M.; Wu, T.; Ren, B.*; Ouyang, Z.*; He, C.* Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution. Nat. Biotech. 2020, on-line. [pdf]

Wu, T.; Lyu, R.; You, Q.; He, C. Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ. Nat. Methods 2020, 17, 515-523. [pdf]

Liu, J.; Dou, X.; Chen, C.; Chen, C.; Liu, C.; Xu, M. M.; Zhao, S.; Shen, B.; Gao, Y.*; Han, D.*; He, C.* N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. Science 2020, 367, 580-586. [pdf]