Research Highlights
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Welcome to the He group!

Recent Publications:

Zhou, L.; Bosscher, M.; Zhang, C.; Ozcubukcu, S.; Zhang, L.; Zhang, W.; Li, C. J.; Liu, J.; Jensen, M. P.; Lai, L.; He, C. A protein engineered to bind uranyl selectively and with femtomolar affinity. Nat. Chem. 2014, 6, 236-241. [pdf][news][news]

Wang, X.; Lu, Z.; Gomez, A.; Hon, G. C.; Yue, Y.; Han, D.; Fu, Y.; Parisien, M.; Dai, Q.; Jia, G.; Ren, B.; Pan, T.; He, C. N6-methyladenosine-dependent regulation of messenger RNA stability.Nature. 2014, 505, 117-120. [pdf] [news]

Liu, J.; Yue, Y.; Han, D.; Wang, X.; Fu, Y.; Zhang, L.; Jia, G.; Yu, M.; Lu, Z.; Deng, X.; Dai, Q.; Chen, W.; He, C. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol. 2013. [ahead of print] [pdf]

Song, C. X.; Szulwach, K. E.; Dai, Q.; Fu, Y.; Mao, S. Q.; Lin, L.; Street, C.; Li, Y.; Poidevin, M.; Wu, H.; Gao, J.; Liu, P.; Li, L.; Xu, G. L.; Jin, P.*; He, C.* Genome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming. Cell. 2013, 153, 678-691. [pdf] [cover]

Deng, X.; Weerapana, E.; Ulanovskaya, O.; Sun, F.; Liang, H.; Ji, Q.; Ye, Y.; Fu, Y.; Zhou, L.; Li, J.; Zhang, H.; Wang, C.; Alvarez, S.; Hicks, L. M.; Lan, L.; Wu, M.; Cravatt, B. F.*; He, C*. Proteome-wide Quantification and Characterization of Oxidation-Sensitive Cysteines in Pathogenic Bacteria. Cell Host & Microbe. 2013, 13, 358-370. [pdf]

Ji, Q.; Zhang, L.; Jones, M. B.; Sun, F.; Deng, X.; Liang, H.; Cho, H.; Brugarolas, P.; Gao, Y. N.; Peterson, S. N.; Lan, L.; Bae, T.; He, C. Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc. Natl. Acad. Sci. 2013.ahead of print.[pdf]

Zhang, L.; Szulwach, K. E.; Hon, G. C.; Song, C. X.; Park, B.; Yu, M.; Lu, X.; Dai, Q.; Wang, X.; Street, C. R.; Tan, H.; Min, J. H.; Ren, B.; Jin, P.; He, C. Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nat. Commun. 2013, 4, 1517. [pdf]

Yu, M.; Hon, G. C.; Szulwach, K. E.; Song, C. X.; Jin, P.; Ren, B.; He, C. Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nat. Protoc. 2012, 7, 2159-2170.[pdf]

Zheng, G.; Dahl, J. A.; Niu, Y.; Fedorcsak, P.; Huang, C.-M.; Li, Charles J.; Vågbø, Cathrine B.; Shi, Y.; Wang, W.-L.; Song, S.-H.; Lu, Z.; Bosmans, Ralph P. G.; Dai, Q.; Hao, Y.-J.; Yang, X.; Zhao, W.-M.; Tong, W.-M.; Wang, X.-J.; Bogdan, F.; Furu, K.; Fu, Y.; Jia, G.; Zhao, X.; Liu, J.; Krokan, Hans E.; Klungland, A.*; Yang, Y.-G.*; He, C.* ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Mol. Cell. 2013, 18-29.[pdf][news]

Hitosugi, T.; Zhou, L.; Elf, S.; Fan, J.; Kang, H.-B.; Seo, Jae H.; Shan, C.; Dai, Q.; Zhang, L.; Xie, J.; Gu, T.-L.; Jin, P.; Ale kovi, M.; LeRoy, G.; Kang, Y.; Sudderth, Jessica A.; DeBerardinis, Ralph J.; Luan, C.-H.; Chen, Georgia Z.; Muller, S.; Shin, Dong M.; Owonikoko, Taofeek K.; Lonial, S.; Arellano, Martha L.; Khoury, Hanna J.; Khuri, Fadlo R.; Lee, Benjamin H.; Ye, K.; Boggon, Titus J.; Kang, S.; He, C.*; Chen, J.* Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth. Cancer Cell. 2012, 22, 585-600.[pdf]

Song, C. X.; Yi, C.; He, C. Mapping recently identified nucleotide variants in the genome and transcriptome. Nat. Biotechnol. 2012, 30, 1107-1116.[pdf]

Yu, M.; Hon, G.C.; Szulwach, K.E.; Song, C.X.; Zhang, L.; Kim, A.; Li, X.K.; Dai, Q.; Shen, Y.; Park, B.; Min, J.H.; Jin, P.*; Ren, B.*; He, C.* Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome. Cell. 2012, 149, 1368-1380. [pdf][news]

Sun, F.; Ding, Y.; Ji, Q.; Liang, Z.; Deng, X.; Wong, C. C.; Yi, C.; Zhang, L.; Xie, S.; Alvarez, S.; Hicks, L. M.; Luo, C.; Jiang, H.; Lan, L.; He, C. Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc. Natl. Acad. Sci. 2012, 109, 15461-15466.[pdf]

Sun, F.; Liang, H.; Kong, X.; Xie, S.; Cho, H.; Deng, X.; Ji, Q.; Zhang, H.; Alvarez, S.; Hicks, L. M.; Bae, T.; Luo, C.; Jiang, H.; He, C. Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc. Natl. Acad. Sci. 2012. ahead of print. [pdf]

Yi, C.; Chen, B.; Qi, B.; Zhang, W.; Jia, G.; Zhang, L.; Li, C. J.; Dinner, A. R.; Yang, C. G.*; He, C.* Duplex interrogation by a direct DNA repair protein in search of base damage. Nat. Struct. Mol. Biol. 2012, 19, 671-676. [pdf] [cover]

Zhang, L.; Lu, X.Y.; Lu, J.Y.; Liang, H.H.; Dai, Q.; Xu, G.L.; Luo, C.; Jiang, H.L.; He, C. Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat. Chem. Biol. 2012, 8, 328-330. [pdf]

Song, C. X.; Clark, T. A.; Lu, X. Y.; Kislyuk, A.; Dai, Q.; Turner, S. W.; He, C.*; Korlach, J.* Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine. Nat. Methods. 2012. 9, 75-77. [pdf]

Jia, G.; Fu, Y.; Zhao, X.; Dai, Q.; Zheng, G.; Yang, Y.; Yi, C.; Lindahl, T.; Pan, T.; Yang, Y. G.; He, C. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 2011, 7, 885-887.[pdf] [news]

Qian, Y.; Karpus, J.; Kabil, O.; Zhang, S. Y.; Zhu, H. L.; Banerjee, R.; Zhao, J.; He, C. Selective fluorescent probes for live-cell monitoring of sulphide. Nat. Commun. 2011, 2, 495.[pdf][news]

He, Y. F.; Li, B. Z.; Li, Z.; Liu, P.; Wang, Y.; Tang, Q.; Ding, J.; Jia, Y.; Chen, Z.; Li, L.; Sun, Y.; Li, X.; Dai, Q.; Song, C. X.; Zhang, K.; He, C.; Xu, G. L. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011, 333, 1303-1307.[pdf]

Ito, S.; Shen, L.; Dai, Q.; Wu, S. C.; Collins, L. B.; Swenberg, J. A.; He, C.; Zhang, Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011, 333, 1300-1303. [pdf]

Song, C.X.; Szulwach, K.E.; Fu, Y.; Dia, Q.; Yi, C.; Li, X.; Li, Y.; Chen, C.-H.; Zhang, W.; Jian, X.; Wang, J.; Zhang, L.; Looney, T.J.; Zhang, B.; Godley, L.A.; Hicks, L.M.; Lahn, B.T.; Jin, P.*; He, C.* "Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine" Nat. Biotechnol.201129, 68.[pdf][news]



08/25/2011: Opening Ceremony- Synthetic and Functional Biomolecules Center (SFBC)-PKU. [news]