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Welcome to the He Group!


An epigenetics gold rush: new controls for gene expression More...


Epitranscriptome analysis is Method of the Year 2016 (Nature Methods) More...


Visit Center for Dynamic RNA Epitranscriptomes (CEGS-CDRE) website CDRE


Prof. Chuan He to lead Chicago’s first Center of Excellence in Genomic Science (CEGS) More...


Recent Publications:

Zhao B.S.; Wang X.; Beadell A.V.; Lu Z.; Shi H.; Kuuspalu A.; Ho R.K.; He C. m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition. Nature 2017, 542, 475-478.[pdf]

Liu, F.; Clark, W.; Luo, G.; Wang, X.; Fu, Y.; Wei, J.; Wang, X.; Hao, Z,.; Dai, Q.; Zheng, G.; Ma, H.; Han, D.; Evans, M.; Klungland, A.; Pan, T.; He, C. ALKBH1-mediated tRNA demethylation regulates translation. Cell 2016, 167, 816-828.[pdf] [news]

Dominissini, D.; Nachtergaele, S.; Moshitch-Moshkovitz, S.; Peer, E.; Kol, N.; Ben-Haim, M. S.; Dai, Q.; Di Segni, A.; Salmon-Divon, M.; Clark, W. C.; Zheng, G.; Pan, T.; Solomon, O.; Eyal, E.; Hershkovitz, V.; Han, D.; Doré, L. C.; Amariglio, N.; Rechavi, G.; He, C. The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA. Nature 2016, 530, 441-446. [pdf] [news]

Wang, X.; Zhao, B. S.; Roundtree, I. A.; Lu, Z.; Han, D.; Ma, H.; Weng, X.; Chen, K.; Shi, H.; He, C. N6-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell 2015, 161, 1388-1399. [pdf]

Greer, E. L.; Blanco, M. A.; Gu, L.; Sendinc, E.; Liu, J.; Aristizábal-Corrales, D.; Hsu, C. H.; Aravind, L.; He, C.; Shi, Y. DNA Methylation on N6-Adenine in C. elegans. Cell 2015, 161, 868-878. [pdf]

Fu, Y.; Luo, G. Z.; Chen, K.; Deng, X.; Yu, M.; Han, D.; Hao, Z.; Liu, J.; Lu, X.; Doré, L. C.; Weng, X.; Ji, Q.; Mets, L.; He, C. N6-methyldeoxyadenosine marks active transcription start sites in chlamydomonas. Cell 2015, 161, 879-892. [pdf]

Zhang, G.; Huang, H.; Liu, D.; Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J.; Li, C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.; Chen, D. N6-methyladenine DNA modification in Drosophila. Cell 2015, 161, 893-906. [pdf]